NEW DELHI: A genetic region previously known to increase the risk of Alzheimer’s in African-Americans, has been linked to an increased risk of stroke. In addition, a new study published in the journal Nature showed that the frequency of this genetic region known as COBL was higher in people with neuropathy in South Asians, including Indian patients.
Based on Dr. Kameshwar Prasadformer head of neurology at AIIMSwho is currently the director of Rajendra Prasad Institute of Health Sciences (RIMS), Ranchi, found that the presence of COBL increased the risk of stroke in South Asians. TS Prasad speak. He led the team from India on the Nature study that involved about two million stroke patients and two million people without stroke. The individuals studied came from five different ancestry: Europeans, Africans, Hispanics, East Asians, and South Asians.
Dr. Prasad said their team contributed data on 4,088 individuals – 1,609 cases of stroke and 2,479 cases of controls – which is part of the South Asian group. He added: “This study resulted in the identification of 89 genetic regions, of which 61 were newly identified for the first time for stroke while 28 confirmed the signals already identified by other studies. before,” he added.
The discovery of such genetic regions could pave the way for the targeted discovery of drugs that are potentially more effective in specific populations such as South Asians. It could also be used to predict stroke and help develop targeted therapy for the disease, the neurologist said.
In 2019, the estimated number of stroke cases in India was 1.29 million and the death toll from stroke was 6.99,000. The treatments available to date are mechanical or chemical removal of the clot.
Prevention is also based on the ‘one size fits all’ principle. Dr Prasad explains: “The discovery of stroke-causing genes in our population will allow for precise identification of those at high risk, and targeted therapy to disable the gene could allow targeted prevention and specific treatment,” explains Dr. Prasad.
Based on Dr. Kameshwar Prasadformer head of neurology at AIIMSwho is currently the director of Rajendra Prasad Institute of Health Sciences (RIMS), Ranchi, found that the presence of COBL increased the risk of stroke in South Asians. TS Prasad speak. He led the team from India on the Nature study that involved about two million stroke patients and two million people without stroke. The individuals studied came from five different ancestry: Europeans, Africans, Hispanics, East Asians, and South Asians.
Dr. Prasad said their team contributed data on 4,088 individuals – 1,609 cases of stroke and 2,479 cases of controls – which is part of the South Asian group. He added: “This study resulted in the identification of 89 genetic regions, of which 61 were newly identified for the first time for stroke while 28 confirmed the signals already identified by other studies. before,” he added.
The discovery of such genetic regions could pave the way for the targeted discovery of drugs that are potentially more effective in specific populations such as South Asians. It could also be used to predict stroke and help develop targeted therapy for the disease, the neurologist said.
In 2019, the estimated number of stroke cases in India was 1.29 million and the death toll from stroke was 6.99,000. The treatments available to date are mechanical or chemical removal of the clot.
Prevention is also based on the ‘one size fits all’ principle. Dr Prasad explains: “The discovery of stroke-causing genes in our population will allow for precise identification of those at high risk, and targeted therapy to disable the gene could allow targeted prevention and specific treatment,” explains Dr. Prasad.
