Alexander University
BioNTech (NASDAQ:BNTX) speak it has begun a phase 1 trial of the BNT165b1 mRNA-based malaria vaccine.
BNT165b1 is the first candidate in the company’s BNT165 program, which aims to develop a multi-antigen malaria vaccine candidate.
BioNTech notes that it aims development of the first mRNA-based vaccine for malaria prevention based on a novel multi-antigen vaccine approach.
The company said it will initially evaluate a set of antigens encoded by the mRNA of the malaria parasite Plasmodium falciparum (P. falciparum) to help select a multi-antigen vaccine candidate for carry out the next phase trials as planned.
This first trial will evaluate the safety, tolerability, and exploratory immunogenicity of the potential vaccine BNT165b1, which expresses certain parts of the extracellular protein (CSP). .
The trial is expected to enroll approximately 60 healthy individuals with no previous or current history of malaria infection at sites in the United States BNT165b1 will be evaluated at three dose levels.
“Our goal is to develop a vaccine that can help prevent malaria and reduce mortality. In the coming months, we aim to evaluate different antigens with rigor science to identify the optimal candidate,” said Özlem Türeci, Co-Founder and Chief Medical Officer of BioNTech.
BioNTech’s BNT165 program is part of the Malaria project announced in July 2021 and has two main goals: First, to develop an effective and well-tolerated mRNA vaccine with long-term protective immunity long-term to prevent blood-borne malaria infection and secondly to sustainable vaccine development solutions manufacturing and sourcing in Africa, including the company’s BioNTainer solution.
Earlier this week, the company said six Shipping in progress The first BioNTainer containers have completed construction in Europe and are being prepared for shipment to Kigali, Rwanda.
The company revealed its plans in February to start producing the mRNA vaccine make in Africa, based on a shipping container solution called BioNTainer.
Each BioNTainer is a clean room equipped with state-of-the-art production solutions.
